Full structural characterization of Shigella flexneri M90T serotype 5 wild-type R-LPS and its galU mutant: glycine residue location in the inner core of the lipopolysaccharide
نویسندگان
چکیده
Antonio Molinaro1,2, Alba Silipo2, Cristina De Castro2, Luisa Sturiale3, Giulia Nigro4, Domenico Garozzo3, Maria Lina Bernardini4,5, Rosa Lanzetta2, and Michelangelo Parrilli2 2Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Via Cintia 4, I-80126 Napoli; 3CNR Istituto per la Chimica e la Tecnologia dei Materiali Polimerici, Viale A. Doria 6, 95125 Catania; 4Dipartimento di Biologia Cellulare e dello Sviluppo, Sapienza-Università di Roma, Via dei Sardi 70, 00185 Roma; and 5Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
منابع مشابه
Full structural characterization of Shigella flexneri M90T serotype 5 wild-type R-LPS and its delta galU mutant: glycine residue location in the inner core of the lipopolysaccharide.
Shigella flexneri is a gram-negative bacterium responsible for serious enteric infections that occur mainly in the terminal ileum and colon. High interest in Shigella, as a human pathogen, is driven by its antibiotic resistance and the necessity to develop a vaccine against its infections. Vaccines of the last generation use carbohydrate moieties of the lipopolysaccharide as probable candidates...
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